Plasmacytoid Medical Definition Merriam-Webster Medical

  1. Medical Definition of plasmacytoid. : resembling or derived from a plasma cell
  2. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive hematologic neoplasm, included among acute myeloid leukemia (AML) and related precursor disorders in the 2008 World Health Organization (WHO) classification of hematological diseases and then classified as a distinct entity among myeloid neoplasms in the 2016 revision [1,2]
  3. Plasmacytoid synonyms, Plasmacytoid pronunciation, Plasmacytoid translation, English dictionary definition of Plasmacytoid. n. Any of various short-lived cells that develop from activated B cells and secrete large numbers of antibodies
  4. Plasmacytoid dendritic cells (pDCs) are a relatively recently discovered cell type that was first characterized in the 1990s. The earliest in vitro studies found that these cells were developmentally and functionally related to DCs. However, pDCs lack dendrite-like projections and instead have the rounded shape of plasma cells. Their name thus derives from the combination of their DC-like.
  5. Plasmacytoid urothelial carcinoma is a rare variant of urothelial carcinoma with defined clinical and pathological characteristics. Diagnostic pitfalls are missing hematuria and no grossly identifiable tumor despite muscle invasive tumor stage
  6. Plasmacytoid urothelial carcinoma (PUC) is a rare urothelial carcinoma (UC) variant with an aggressive phenotype , comprising approximately 3- 5% of patients with muscle-invasive bladder cancer. Histologically, PUC can appear as diffuse sheets of cells or as a discohesive, single-cell and highly infiltrative growth pattern

Plasmacytoid definition of Plasmacytoid by Medical

The Plasmacytoid Dendritic Cell Isolation Kit II allows the isolation of untouched human plasmacytoid dendritic cells (PDCs) from PBMCs. Having evolved from the first-generation kit (# 130-092-207), it now offers even better cell purity and yield in a faster procedure. - US The critical importance of plasmacytoid dendritic cells (pDCs) in viral infection, autoimmunity, and tolerance has focused major attention on these cells that are rare in blood and immune organs of humans and mice. The recent development of an Flt-3 ligand (FL) culture system of bone marrow cells ha Define plasmacytoid lymphocytic lymphoma. plasmacytoid lymphocytic lymphoma synonyms, plasmacytoid lymphocytic lymphoma pronunciation, plasmacytoid lymphocytic lymphoma translation, English dictionary definition of plasmacytoid lymphocytic lymphoma. n. pl. lym·pho·ma·ta or lym·pho·mas 1. Any of various malignant tumors that arise from the.

BEVEZETÉS - Irodalmi adatok alapján feltételezhető, hogy a nem T-, nem B-sejtes CD4+/CD56+ lymphoid daganatok klinikailag és immunfenotípus szerint többféle entitást képviselnek. Bár a sejtes eredet és osztályozás még ellentmondásos, néhány betegség világosan elkülönülő, klinikailag agresszív kórképet képvisel. ESETISMERTETÉS - Ebben a munkában egy plazmacitoid. DE Kossuth Lajos Gyakorló Gimnáziuma és Általános Iskolája. Arany János téri feladatellátási hely. Csengő utcai feladatellátási hel Blastic Plasmacytoid Dendritic-Cell Neoplasm List of authors. Yung Gonzaga, M.D., and Mayne Fontes, M.D. A 29-year-old man presented with progressive skin lesions on the face, back, trunk, and. Plasmacytoid urothelial carcinoma, which is a characteristic morphology similar to plasma cells, is an unusual variant that is included in the World Health Organization classification of urothelial neoplasms [1, 2].Several studies have recently reported that the plasmacytoid component of a urothelial carcinoma exhibits positive staining for CD138, an immunohistochemical marker for plasma cells.

Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus - Volume 114 Issue 5 - Tetsu Sugimura, Hitoshi Takahashi, Kenta Jounai, Konomi Ohshio, Masaya Kanayama, Kyoko Tazumi, Yoko Tanihata, Yutaka Miura, Daisuke Fujiwara, Norio Yamamot Abstract. Objectives: Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution. Methods: The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years). Results: PUC was pure in 23 cases and mixed with other histologic types in 26 cases plasmacytoid DC precursor or plasmacytoid pre‐dendritic cell Introduction Cell differentiation is defined as the progressive restriction of a cell's developmental potential and increasing specialization of its function, ultimately leading to the formation of specialized cells, tissues, and organs

Korábbi tanulmányok szerint a plazmacitoid DS-ek csak a TLR-eket fejezik ki nyugalmi állapotban, és ezen munkák egyike sem vizsgálta a RIG-I-szerű helikázok és a TLR-ek potenciális együttműködését. Nemrégiben sikerült kimutatnunk, hogy a plazmacitoid DS-ek RIG-I receptort fejeznek ki TLR 7 és 9 specifikus ligandumaival történ Background/Purpose: Plasmacytoid dendritic cells (pDCs) secrete large amounts of type I interferon (IFN) and other cytokines upon activation. pDCs migrate to sites of active disease in lupus. VIB7734 is a monoclonal antibody that selectively targets pDCs for antibody-dependent cellular cytolysis. Methods: VIB7734 was tested in a phase 1, randomized, double-blind, placebo-controlled, multiple. Ian Kunkler, FRCP, FRCR, DMRT, MRCP, discusses the 10-year results of the PRIME 2 trial in patients with breast cancer Ian Kunkler, FRCP, FRCR, DMRT, MRCP, professor and lead of Clinical and.

Bencze, Dóra and Fekete, Tünde and Ágics, Beatrix and Pazmandi, Kitti (2020) A vírusok ellenségei: a humán plazmacitoid dendritikus sejtek. IMMUNOLÓGIAI SZEMLE, 12 (2). pp. 4-20. ISSN 2061-020 If and when effective vaccines for Covid-19 are developed, some will surely rely on a nanoparticle delivery system whose origins lie in decades of painstaking groundwork. Offering a tour of that effort was Dr. Dan Anderson of MIT A Plasmacytoid dendritikus sejtek mellett a PDC más jelentéssel is bír. Ezek a bal oldalon vannak felsorolva. Görgessen le és kattintson az egyesek megtekintéséhez. A (z) PDC összes jelentését kérjük, kattintson a Több gombra. Ha meglátogatja az angol verziót, és szeretné megtekinteni a Plasmacytoid dendritikus sejtek.

Plasmacytoid - definition of Plasmacytoid by The Free

Plasmacytoid Dendritic Cell - an overview ScienceDirect

Definitions for plasmacytoid. plas·ma·cy·toid. Here are all the possible meanings and translations of the word plasmacytoid. Wiktionary(0.00 / 0 votes)Rate this definition: plasmacytoid(Adjective) Of or pertaining to plasma cells Video shows what plasmacytoid means. Of or pertaining to plasma cells. Plasmacytoid Meaning. How to pronounce, definition audio dictionary. How to say plasma.. Plasmacytoid lymphocyte has an oval nucleus with condensed chromatin. There is slightly more cytoplasm present than in small lymphocytes. Plasmacytoid Lymphocyte - 1

Background . Plasmacytoid urothelial carcinoma is a rare and aggressive histologic variant of high-grade carcinoma of the urinary bladder. Few than 250 cases have been reported in the urinary bladder till January 2019. In this paper, a case series of unusual gastrointestinal carcinomas with plasmacytoid morphology was included. Only one similar case of the stomach was previously published and. ABOUT BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM (BPDCN) BPDCN is a rare form of blood cancer that has features of both leukemia and lymphoma, with characteristic skin lesions, lymph node.

Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of Lactococcus lactis strain plasma in mice. Bioscience, Biotechnology, and Biochemistry, Vol. 83, Issue. 11, p. 2140 The EasySep™ Human Plasmacytoid DC Enrichment Kit is designed to isolate plasmacytoid dendritic cells (pDC) from fresh peripheral blood mononuclear cells by negative selection. Unwanted cells are targeted for removal with Tetrameric Antibody Complexes recognizing non-pDCs and dextran-coated magnetic particles The Plasmacytoid Dendritic Cell Isolation Kit is designed for the isolation of untouched mouse plasmacytoid dendritic cells (PDCs) from single-cell suspensions of lymphoid organs. - 日本 Your selected URL is placed in a country different from your estimated location Blastic plasmacytoid dendritic cell neoplasm (BPDCN), previously known as CD4+/CD56+ hematodermic neoplasm or blastic NK-cell lymphoma, is a malignant neoplasm composed of immature hematopoietic cells thought to be precursors of plasmacytoid dendritic cells. 1-5 The most frequent manifestation is that of an asymptomatic patient with a skin lesion. 2, 3, 6, 7 Myeloid leukemia cutis (LC) is an important consideration in the differential diagnosis of BPDCN plasmacytoid translation in English - German Reverso dictionary, see also 'plasm',plastic money',plastic bomb',planetoid', examples, definition, conjugatio


Lymphoplasmacytic lymphoma (LPL) is a B cell neoplasm of small lymphocytes, plasmacytoid lymphocytes and plasma cells (Swerdlow: WHO Classification of Tumours of Haematopoeitic and Lymphoid Tissue, 4th Edition, 2017) Usually involves bone marrow, sometimes lymph nodes and splee Plasmacytoid urothelial carcinoma (PUC) is a unique variant of invasive urothelial carcinoma characterized by tumor cells that exhibit a striking resemblance to plasma cells, and it is known to have an aggressive behavior. 8-20 The 2016 WHO classification now recognizes signet ring cell and diffuse urothelial carcinoma as similar to PUC. 5 Plasmacytoid urothelial carcinoma was first. plasmacytoid — adjective Of or pertaining to plasma cells Wiktionary. plasmacytoid — plas·ma·cy·toid .plaz mə sī .tȯid adj resembling or derived from a plasma cell Medical dictionar Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy.It was initially regarded as a form of lymphocyte-derived cutaneous lymphoma and alternatively named CD4+CD56+ hematodermic tumor, blastic NK cell lymphoma, and agranular CD4+ NK cell leukemia. Later, however, the disease was determined to be a malignancy of plasmacytoid dendritic cells rather than.

Plasmacytoid urothelial carcinoma (PUC) is a variant of infiltrating urothelial carcinoma that is characterized by tumor cells that have striking morphologic resemblance to and immunohistochemical overlap with plasma cells, and that harbors CDH1 mutation. Plasmacytoid urothelial carcinoma can be widely infiltrative and may permeate the urinary. Plasmacytoid Dendritic Cells and Its Signature Cytokine IFN-[alpha] Were More Abundant in Peripheral Blood of IgAN Patients. Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropath Hướng dẫn cách phát âm: Học cách phát âm plazmacitoid trong Tiếng Hungary bằng giọng phát âm bản xứ. plazmacitoid dịch tiếng Anh

Plasmacytoid urothelial carcinoma of the bladder

Plasmacytoid dendritic cells were initially identified as a unique cell subset that respond to viruses with rapid and massive production of IFN‐I, and play a central role in the antiviral immune response. 2 Moreover, pDCs could also respond to certain non‐viral pathogens such as bacteria (e.g. Chlamydia pneumoniae) 51 and apicomplexan. Background The oncolytic virus, coxsackievirus A21 (CVA21), has shown promise as a single agent in several clinical trials and is now being tested in combination with immune checkpoint blockade. Combination therapies offer the best chance of disease control; however, the design of successful combination strategies requires a deeper understanding of the mechanisms underpinning CVA21 efficacy. On 12 November 2020, the Committee for Medicinal Products for Human Use adopted a positive opinion following a re-examination procedure, recommending the granting of a marketing authorisation for the medicinal product Elzonris 1, intended for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN).. The applicant for this medicinal product is Stemline Therapeutics B.V

Plasmacytoid Urothelial Carcinoma: Response to

Background/Purpose: No approved targeted therapies have been developed for cutaneous lupus erythematosus (CLE), a disfiguring autoimmune disease that severely impairs quality of life.1 BIIB059 is a humanized monoclonal antibody that binds blood dendritic cell antigen 2 (BDCA2), a receptor uniquely expressed on plasmacytoid dendritic cells, leading to BDCA2 internalization and subsequent. Autoantibodies to self-DNA are a defining feature of systemic lupus erythematosus (SLE), yet the mechanisms of their development remain poorly understood. Soni et al. show that anti-DNA autoreactivity is driven by extrafollicular B cell differentiation into short-lived plasmablasts, which is facilitated by plasmacytoid dendritic cells, type I interferon, and endosomal Toll-like receptors 7 and 9 Abstract. Recent advances reveal that metabolic reprogramming is required for adequate antiviral responses of dendritic cells (DCs) that possess the capacity to initiate innate a plasmacytoid dendritic cells Innate immunity is a conserved host defense mechanism and its key functions of are 1) to differentiate between harmful and non-harmful materials; 2) to initiate the first line of immune response; and 3) to recruit and prime the effector cells of the adaptive immune system. Dendriti OncLive will be LIVE with OncLive News Network: On Location at the virtual 2020 San Antonio Breast Cancer Symposium. Each day, we will broadcast a series of interviews with top thought leaders, to.

The expansion of dendritic cells (CD11c +) and plasmacytoid dendritic cells (CD11c + PDCA +) in the Fcgr2b −/− mice diminished in the absence of Sting (Figures 3E and 3F). The reduction of T effector memory cells (CD3 + CD4 + CD62L lo CD44 hi ), germinal center B cells (B220 + GL7 + ), and CD4 + ICOS + cells in the double-deficient mice. 20.7k Likes, 129 Comments - Ally Brooke (@allybrooke) on Instagram: I will be surprising #BPDCN (blastic plasmacytoid dendritic cell neoplasm) survivor Caitlin i BackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. Most patients with BPDCN have skin lesions and simultaneous inv..

Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I interferon (IFN-α/β) in response to foreign nucleic acids. Combined with their antigen presentation capacity, this powerful functionality enables pDCs to orchestrate innate and adaptive immune responses. pDCs combine features of both lymphocytes and classical dendritic cells and display unique. The BPDCN cell of origin is the plasmacytoid dendritic cell (pDC) precursor. The diagnosis of BPDCN is based on the immunophenotypic diagnostic triad of CD123, CD4, and CD56, as well as other markers. The World Health Organization (WHO) termed this disease BPDCN in 2008; previous names included blastic NK cell lymphoma and agranular CD4+/CD56. Italian Translation for plasmacytoid - dict.cc English-Italian Dictionar Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is very often misdiagnosed and under-reported. Diagnosing a patient with BPDCN is difficult. The skin is the most frequently involved site of disease (80 percent of cases). However, BPDCN usually progresses with bone marrow involvement and a decrease in red blood cell, white blood cell and.

Plasmacytoid Dendritic Cell Isolation Kit II, human

形質細胞様樹状細胞(pDC;plasmacytoid dendritic cells)は、ウイルス感染に対抗する主要な番人であると考えられています. pDCの前駆体は、主に1型インターフェロンを産生し、自然免疫と適応免疫を結びつける独特の能力を持っています ABOUT BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM (BPDCN) BPDCN is a rare form of blood cancer that has features of both leukemia and lymphoma, with characteristic skin lesions, lymph node involvement, and frequent spread to the bone marrow. This aggressive cancer requires intense treatment often followed by stem cell transplant Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive disease with historically poor outcomes. It's a bone marrow blood cancer that has a unique clinical predisposition to affecting the skin - so that makes it kind of unique compared to the other myeloid diseases said Naveen Pemmaraju, MD, [ Plasmacytoid dendritic cells (PDCs) are scarce in the human duodenal mucosa. Biopsy specimens from duodenal mucosa of celiac disease patients and controls were digested with collagenase after. ELZONRIS ® (tagraxofusp-erzs) emerges to target CD123 and fight Blastlc Plasmacytoid Dendritic Cell Neoplasm (BPDCN), a deadly hematologic cancer. 1,2 FROM A DEADLY DISEASE RISES A DURABLE RESPONSE Tagraxofusp-erzs (ELZONRIS) Is the First and Only FDA-Approved Treatment for BPDCN Recommended by the NCCN Clinical Practice Guidelines in Oncology.

The BPDCN cell of origin is the plasmacytoid dendritic cell (pDC) precursor. The diagnosis of BPDCN is based on the immunophenotypic diagnostic triad of CD123, CD4, and CD56, as well as other markers Átprogramozott anyagcsere folyamatok jellemzése és új antivirális szabályozó mechanizmusok azonosítása humán plazmacitoid dendritikus sejtekben 15.090 bezá Hungarian Translation for plasmacytoid dendritic cells pDCs - dict.cc English-Hungarian Dictionar Title !5 óõÆ ÓqKÁ«áb ·KýEÿà d h¸ç¸. å5fÆ /Èþc§+ÌÊ ­Ö Æ(½ CË óæÉv^ [: ~ $ æD Âø Author: õ ]õ ðK Ûâcäý åG óO ² ²ñªó öIòÈ~èµÞ 2®M Áå´ç Lzf =«t §ç¿

Hungarian Translation for plasmacytoid - dict.cc English-Hungarian Dictionar Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon

Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells that circulate in the blood and peripheral organs and rapidly secrete large amounts of type I interferons (IFNs) following activation Stain: May-Grnwald-Giemsa (MGG). The plasmacytoid lymphocyte is an activated B lymphocyte to be transformed into a plasma cell. The cytoplasm is more basophilic and the chromatin pattern is more clumped than in a virgin small lymphocyte. When the cell contains numerous immunoglobulin inclusions (globular or crystallin inclusions, vacuoles) such a cell is called Mott cell Plasmacytoid urothelial carcinoma (PUC) is a rare variant of urothelial carcinoma characterized by neoplastic cells morphologically resembling plasma cells. PUC is typically aggressive, high-stage at presentation, and associated with poor outcomes. Recurrence is common in PUC, with the majority of recurrences occurring in the peritoneum The morphology of plasmacytoid variant tumors was similar to lobular breast carcinoma and diffuse gastric carcinoma, both of which also have frequent CDH1 mutations. Patients with plasmacytoid variant cancer had a poorer survival rate, increased incidence of recurrence, and an increased incidence of peritoneal spread compared to patients with other types of bladder cancer Plasmacytoid dendritic cells (pDCs) are specialized white blood cells responsible for a wide range of immune functions, most notably production of the antiviral factor, type I interferon. We have discovered a previously unknown population of pDCs in human blood, bone marrow, and tonsil that is morphologically, phenotypically, and genetically distinct from most pDCs

M-CSF: a novel plasmacytoid and conventional dendritic

  1. The EasySep™ Human Plasmacytoid DC Isolation Kit is designed to isolate plasmacytoid dendritic cells (pDCs) from human peripheral blood mononuclear cells (PBMCs) or leukapheresis by immunomagnetic negative selection. The EasySep™ procedure involves labeling unwanted cells with antibody complexes and magnetic particles
  2. Listen to plasmacytoid | SoundCloud is an audio platform that lets you listen to what you love and share the sounds you create.. 1 Followers. Stream Tracks and Playlists from plasmacytoid on your desktop or mobile device
  3. A plasmacytoid lymphocyte looks like a cross between a lymphocyte and a plasma cell. Lymphocytes just wait around on duty until they are called upon to react to an infection. Under a microscope they look like a cell that's all nucleus and not much else. Imagine an egg that is all yolk
  4. Definition / general. Aggressive carcinoma defined by SMARCB1 gene mutations and associated loss of immunohistochemical expression. Provisional entity in El-Naggar: WHO Classification of Head and Neck Tumors, 4th Edition, 2017
  5. Plasmacytoid dendritic cells (pDCs) are natural interferon α (IFNα)-producing cells. Despite their importance to antiviral defense, autoimmunity, and ischemic liver graft injury, because DC subsets are rare and heterogeneous, basic questions about liver pDC function and capacity to make cytokines remain unanswered
  6. ELZONRIS is a CD123-directed cytotoxin for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and in pediatric patients 2 years and older IMPORTANT SAFETY INFORMATION Boxed WARNING: CAPILLARY LEAK SYNDROM
  7. Dr. Iain McInnes discusses new research suggesting that plasmacytoid dendritic cells play a critical role in the spontaneous breach of self tolerance in rheu..

Plasmacytoid dendritic cells definition of Plasmacytoid

Plasmacytoid lymphocytic lymphoma - definition of

Video: Plazmacitoid dendritikus sejtes leukaemia

Citoszólikus szenzorok aktivitásának és szabályozó

Plasmacytoid DCs (pDCs) are a rare population of circulating cells specialized in the production of large amounts of type I IFNs (IFN-α/β) in response to viral infections (Cella et al., 1999; Siegal et al., 1999).This ability is linked to their unique intracellular expression of toll-like receptor (TLR) 7 and TLR9 (Kadowaki et al., 2001), which recognize single-stranded (ss) viral RNA and. Plasmacytoid dendritic cells (pDCs) are renowned for their production of type 1 interferon in response to viral infection, which is signified by Toll-like receptor (TLR) activation. Here, blood dendritic cell antigen 2(BDCA2), a C-type lectin receptor expressed uniquely on pDCs, is shown to block the ultimate effectors of TLR signaling via a novel pathway Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy with historically poor outcomes. It typically manifests as asymptomatic skin lesions and cytopenias, which result from bone marrow involvement. Less commonly, it will present in lymph nodes or visceral organs as well..

Englisch: plasmacytoid dendritic cell. 1 Definition. Plasmazytoide dendritische Zellen, kurz pDCs, sind Zellen des unspezifischen Immunsystems, die im Blut zirkulieren und in peripheren lymphatischen Organen vorkommen. 2 Hintergrund. Plasmazytoide dendritische Zellen stellen weniger als 0,4% der mononukleären Zellen des peripheren Blutes The plasmacytoid urothelial carcinoma of the bladder (PUC) and the micropapillary carcinoma of the bladder (MPC) represent two of several rare variants of urothelial carcinoma, which were included in the World Health Organisation (WHO) classification in 2004 . Each of these subtypes accounts for approximately 3-5% of UC in patients with muscle. ABOUT BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM BPDCN is a rare form of blood cancer that has features of both leukemia and lymphoma, with characteristic skin lesions, lymph node involvement, and frequent spread to the bone marrow. This aggressive cancer requires intense treatment often followed by stem cell transplant Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is an aggressive neoplasm which is typically CD4+, CD56+, and CD123+. There is limited information regarding CD103 expression on blastic plasmacytoid dendritic cell neoplasms. We identified six cases of BPDCN and all six had at least partial CD103 expression (31-92% positive) with the majority having significant expression of CD103 Montero J, Stephansky J, Cai T, Griffin GK, Cabal-Hierro L, Togami K, Hogdal LJ, Galinsky I, Morgan EA, Aster JC, Davids MS, LeBoeuf NR, Stone RM, Konopleva M, Pemmaraju N, Letai A, Lane AA (2017) Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax. Cancer Discov 7:156-164 Both humoral and cellular immune mechanisms are involved in the onset and progression of autoimmune responses in systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of SLE via the dysregulation of type I interferon (IFN) production; these cells act together with activated myeloid DCs (mDCs) to amplify the vicious pathogenic spiral of.

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